髓系、**、混合系白血病易位基因10抗体
规格：1mg/1ml
英文名： AF10
别名： AF 10; AF10; AF10_HUMAN; ALL 1 fused gene from chromosome 10; ALL1 fused gene from chromosome 10; ALL1-fused gene from chromosome 10 protein; MLLT 10; MLLT10; Myeloid/lymphoid or mixed lineage leukemi
分子量： 109kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human AF10
交叉反应：Human, Mouse, Rat, Pig, Cow, Sheep,
细胞定位：细胞核
髓系、**、混合系白血病易位基因10抗体产品介绍：Function: Probably involved in transcriptional regulation. In vitro or as fusion protein with MLL has transactivation activity. Binds to cruciform DNA. Subunit: Self-associates. Interacts with FSTL3 isoform 2; the interaction enhances MLLT10 in vitro transcriptional activity and self-association. Interacts with YEATS4. Interacts with SS18. Interacts with DOT1L. Subcellular Location: Nucleus. Tissue Specificity: Expressed abundantly in testis. Post-translational modifications: Phosphorylated upon 髓系、**、混合系白血病易位基因10抗体DNA damage, probably by ATM or ATR. DISEASE: Note=A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with MLL/HRX. The result is a rogue activator protein. Note=A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM. 髓系、**、混合系白血病易位基因10抗体Similarity: Contains 2 PHD-type zinc fingers. Gene ID: 8028 Database links: Entrez Gene: 8028 Human Entrez Gene: 17354 Mouse Omim: 602409 Human SwissProt: P55197 Human SwissProt: O54826 Mouse Unigene: 30385 Human Unigene: 209175 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
髓系、**、混合系白血病易位基因10抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid