雌**调节蛋白LIV1/锌转运蛋白抗体
规格：1mg/1ml
英文名： SLC39A6
别名： LIV1; LIV 1; LIV-1; solute carrier family 39, member 6; solute carrier family 39 (zinc transporter), member 6 isoform 1; Zinc transporter ZIP6; Zrt- and Irt-like protein 6; ZIP-6; Endoplasmic reticulu
分子量： 82kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human SLC39A6
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
雌**调节蛋白LIV1/锌转运蛋白抗体产品介绍：background: LIV-1 is expressed as two isoforms. LIV-1 is a multi-pass cell membrane protein that is 749 amino acids in length and is expressed abundantly in breast, prostate, placenta, kidney, pituitary and corpus callosum, as well as in cells derived from various types of cancers affecting the glands, cervix and lungs. LIV-1 is a member of the ZIP transporter protein family which consists of 14 members that transport zinc. LIV-1 transports zinc from its position on the plasma membrane into the cytosol of the cell and contains a histidine-rich transmembrane domain which is thought to bind zinc and aid in its transportation. LIV-1 is thought to be important for zinc uptake in neuroblastoma cells and may also be crucial for maintaining zinc homeostasis, a process which aids in the prevention of cancer and disease.雌**调节蛋白LIV1/锌转运蛋白抗体 Activated estrogen receptors are thought to regulate LIV-1 expression at the level of transcription, via the mRNA precursor to LIV-1 which associates with estrogen receptors that are activated by growth factors and estradiol. LIV-1 is upregulated in hormone-rich tissue, including breast and cervical cancer, where it is thought to affect cell motility and may play an important role in tumor development and metastasis. Conversely, less aggressive tumors may contain high levels of LIV-1 that could lead to apoptosis, indicating a dual role for LIV-1 in tumor suppression. Function: May act as a zinc-influx transporter. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity:雌**调节蛋白LIV1/锌转运蛋白抗体 Highly expressed in the breast, prostate, placenta, kidney, pituitary and corpus callosum. Weakly expressed in heart and intestine. Also highly expressed in cells derived from an adenocarcinoma of the cervix and lung carcinoma. Post-translational modifications: N-glycosylated. Similarity: Belongs to the ZIP transporter (TC 2.A.5) family. Gene ID: 25800 Database links: Entrez Gene: 480159 Dog Entrez Gene: 25800 Human Entrez Gene: 106957 Mouse Entrez Gene: 291733 Rat Omim: 608731 Human SwissProt: Q13433 Human SwissProt: Q8C145 Mouse SwissProt: Q4V887 Rat Unigene: 729034 Human Unigene: 21688 Mouse Unigene: 99415 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
雌**调节蛋白LIV1/锌转运蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid