拓普西异构酶Ⅰ抗体
规格：1mg/1ml
英文名： Topoisomerase I
别名： DNA topoisomerase 1; DNA topoisomerase I; NUP98 fusion gene; TOP 1; TOP I; TOP1; TOP1_HUMAN; TOPI; Topoisomerase 1; Topoisomerase1; TopoisomeraseI; Type I DNA topoisomerase.
分子量： 91kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Topoisom
交叉反应：Human, Mouse, Rat, Rabbit,
拓普西异构酶Ⅰ抗体细胞定位：细胞核
产品介绍：background: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008] Function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another. Subcellular Location: Nucleus, nucleolus. Nucleus, nucleoplasm. Diffuse nuclear localization with some enrichment in拓普西异构酶Ⅰ抗体 nucleoli. On CPT treatment, cleared from nucleoli into nucleoplasm. Sumolyated forms found in both nucleoplasm and nucleoli. Post-translational modifications: Sumoylated. Lys-117 is the main site of sumoylation. Sumoylation plays a role in partitioning TOP1 between nucleoli and nucleoplasm. Levels are dramatically increased on camptothecin (CPT) treatment. DISEASE: Note=A chromosomal aberration involving TOP1 is found in a form of therapy-related myelodysplastic syndrome. Translocation t(11;20)(p15;q11) with NUP98. Similarity: Belongs to 拓普西异构酶Ⅰ抗体the eukaryotic type I topoisomerase family. Gene ID: 7150 Database links: Entrez Gene: 7150 Human Entrez Gene: 21969 Mouse Entrez Gene: 64550 Rat Entrez Gene: 281539 Cow Omim: 126420 Human SwissProt: P11387 Human SwissProt: Q04750 Mouse SwissProt: Q9WUL0 Rat Unigene: 472737 Human Unigene: 712686 Human Unigene: 217233 Mouse Unigene: 91572 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
拓普西异构酶Ⅰ抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid