谷草转氨酶2抗体
规格：1mg/1ml
英文名： GOT2
别名： ASPATA; FABP pm; Got 2; Aspartate aminotransferase; Aspartate aminotransferase 2; Aspartate aminotransferase, mitochondrial; EC 2.6.1.1; FABP 1; FABPpm; Fatty acid binding protein; FLJ40994; Glutamate
分子量： 45kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GOT2
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：细胞浆 细胞膜 线粒体
谷草转氨酶2抗体产品介绍：background: GOT2 [Glutamate oxaloacetate transaminase] is a ubiquitous pyridoxal phosphate dependent enzyme which exists in both mitochondrial and cytosolic forms. The enzyme plays an important role in amino acid metabolism and in the urea and tricarboxylic acid cycles. The 2 isoenzymes are homodimeric. In liver about 80% of the enzyme activity is mitochondrial in origin, whereas in serum the enzyme activity is largely cytosolic. Although the mitochondrial and soluble forms of GOT are coded by different chromosomes, the 2 show close homology in amino acid sequence and were presumably derived from a common ancestral gene. Serum GOT [with SGPT] 谷草转氨酶2抗体levels are usually elevated in states of hepatocellular injury (injury to the liver cells), the highest levels are associated with hepatitis of a viral origin. High levels are also found after myocardial infarction, when SGPT levels are lower. Function: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids. Subunit: Homodimer. Subcellular Location: 谷草转氨酶2抗体Mitochondrion matrix. Cell membrane. Note=Exposure to alcohol promotes translocation to the cell membrane. Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Gene ID: 2806 Database links: Entrez Gene: 2806 Human Entrez Gene: 14719 Mouse Entrez Gene: 25721 Rat Omim: 138150 Human SwissProt: P00505 Human SwissProt: P05202 Mouse SwissProt: P00507 Rat Unigene: 599470 Human Unigene: 230169 Mouse Unigene: 98650 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
谷草转氨酶2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 细胞生物 细胞凋亡 转录调节因子 激酶和磷酸酶 线粒体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid