神经粘蛋白抗体
规格：1mg/1ml
英文名： Neurocan
别名： Chondroitin sulfate proteoglycan 3; Cspg3; NCAN; NEUR; Neurocan core protein; NCAN_HUMAN.
分子量： 140kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Neurocan
交叉反应：Human, Mouse, Rat,
细胞定位：分泌型蛋白
神经粘蛋白抗体产品介绍：background: Neurocan is the major soluble chondroitin sulfate proteoglycan in the brain. It is thought to play a functional role in axonal growth and guidance and in the establishment of specific neural pathways during embryonic brain development. Neurocan expression in the brain is developmentally regulated. Early on the major form of neurocan consists of a 245kD core protein with approximately two chondroitin sulfate glycosoaminoglycan chains of 22kD each. Later neurocan comprises a 180kD core protein Both forms of neurocan contain only chondroitin 4-sulfate glycosoaminoglycan chains. By virtue of their high expression at sites of neural damage and trauma, 神经粘蛋白抗体chondroitin sulfate proteoglycans, including neurocan, are thought to inhibit successful nerve regeneration. Alternative names: Chondroitin sulfate proteoglycan 3; Cspg3; NCAN; NEUR; Neurocan core protein. Function: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. Subcellular Location: Secreted. Tissue Specificity: Brain. Similarity: Belongs to the aggrecan/versican proteoglycan family. Contains 1 C-type lectin domain. 神经粘蛋白抗体Contains 2 EGF-like domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain. Contains 2 Link domains. Contains 1 Sushi (CCP/SCR) domain. Gene ID: 1463 Database links: Entrez Gene: 1463 Human Entrez Gene: 58982 Rat Omim: 600826 Human SwissProt: O14594 Human SwissProt: P55067 Rat Unigene: 169047 Human Unigene: 10177 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 神经生物学相关蛋白（Neurobiology） 神经粘蛋白(Neurocan)是由神经元分泌的特异性蛋白质,广泛分布于神经系统,可与神经元细胞膜上特异性受体神经粘附分子和神经元胶质细胞黏附分子结合,调节细胞连接,影响轴突生长.而在**神经系统损伤后,Neurocan的表达增加,并抑制轴突生长.Neurocan在**神经系统的形成和损伤后的修复都扮演着重要的角色.
神经粘蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：发育生物学 神经生物学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid