FBXO42蛋白抗体
规格：1mg/1ml
英文名： FBXO42
别名： F box only protein 42; F box protein 42; FBX42; FBXO 42; KIAA1332; FBX42_HUMAN.
分子量： 78kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human FBXO42
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：
FBXO42蛋白抗体产品介绍：background: FBXO42 (F-box only protein 42) is a 717 amino acid protein that contains four Kelch repeats and one N-terminal F-box domain, and belongs to the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors,FBXO42蛋白抗体 IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Function: Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.Specifically recognizes p53/TP53, promoting its ubiquitination anddegradation. Subunit: Component of some SCF complex, composed of CUL1, SKP1,RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53;interaction is FBXO42蛋白抗体direct. Tissue Specificity: Expressed at moderate levels in liver, ovary, kidney, testis and ***** brain, and at low levels in heart and fetal brain, FBXO42 directly interacts with Skp1 p19 and CUL-1. Similarity: Contains 1 F-box domain. Contains 4 Kelch repeats. Gene ID: 54455 Database links: Entrez Gene: 54455 Human Omim: 609109 Human SwissProt: Q6P3S6 Human Unigene: 522384 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
FBXO42蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid