胰岛素样生长因子结合蛋白4抗体
规格：1mg/1ml
英文名： IGFBP4
别名： Insulin-like Growth Factor Binding Protein 4; BP 4; BP4; HT29 IGFBP; IBP 4; IBP4; IGF binding protein 4; IGFBP 4; IBP4_HUMAN.
分子量： 26kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IGFBP4
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep,
细胞定位：分泌型蛋白
胰岛素样生长因子结合蛋白4抗体产品介绍：background: Insulin like growth factor binding protein 4 (IGFBP4) is produced from a DNA sequence encoding the human IGFBP4 protein. Mature human IGFBP4 has a calculated molecular mass of approximately 26 kDa. Due to glycosylation, the recombinant protein migrates as a 32 kDa and 25 kDa protein under reducing and non reducing conditions, respectively. Human IGFBP4 has a potential N-linked glycosylation site and shares approximately 90% amino acid sequence identity with both mouse and rat IGFBP4. IGFBP4 is a member of the superfamily of insulin-like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). IGFBP4 functions as an inhibitor 胰岛素样生长因子结合蛋白4抗体of IGF action and its main function may be to protect cells from overstimulation by IGFs or to allow activation of alternate transmembrane signaling pathways that are inhibited by IGF exposure. IGFBP4 is expressed in multiple tissues including adrenal, testis, spleen, heart, lung, kidney, liver, stomach, hypothalamus, and brain cortex. Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. 胰岛素样生长因子结合蛋白4抗体Subunit: Binds IGF2 more than IGF1. Subcellular Location: Secreted. Similarity: Contains 1 IGFBP N-terminal domain. Contains 1 thyroglobulin type-1 domain. Gene ID: 3487 Database links: Entrez Gene: 374271 Chicken Entrez Gene: 282262 Cow Entrez Gene: 3487 Human Entrez Gene: 16010 Mouse Entrez Gene: 360622 Rat Entrez Gene: 443470 Sheep Omim: 146733 Human SwissProt: Q05716 Cow SwissProt: P22692 Human SwissProt: P47879 Mouse SwissProt: P24854 Pig SwissProt: P21744 Rat SwissProt: Q28893 Sheep Unigene: 462998 Human Unigene: 233799 Mouse Unigene: 160666 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胰岛素样生长因子结合蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 生长因子和** 转录调节因子 糖尿病
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid