髓过氧化物酶抗中性粒细胞胞质IgG抗体
规格：1mg/1ml
英文名： Myeloperoxidase
别名： Myeloperoxidase; MPO; c-ANCA; 89 kDa myeloperoxidase; 84 kDa yeloperoxidase; Myeloperoxidase light chain; Myeloperoxidase heavy chain; EC 1.11.1.7; PERM_HUMAN.
分子量： 77kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Myeloper
交叉反应：Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞浆
髓过氧化物酶抗中性粒细胞胞质IgG抗体产品介绍：background: Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]. Function:髓过氧化物酶抗中性粒细胞胞质IgG抗体 Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Subunit: Tetramer of two light chains and two heavy chains. Subcellular Location: Lysosome. DISEASE: Defects in MPO are the cause of myeloperoxidase deficiency (MPD) [MIM:254600]. MPD is an autosomal recessive defect that results in disseminated candidiasis. Similarity: Belongs to the peroxidase family. XPO subfamily. Gene ID: 4353 Database links: Entrez Gene: 4353髓过氧化物酶抗中性粒细胞胞质IgG抗体 Human Entrez Gene: 17523 Mouse Entrez Gene: 303413 Rat Omim: 606989 Human SwissProt: P05164 Human SwissProt: P11247 Mouse Unigene: 458272 Human Unigene: 4668 Mouse Unigene: 47782 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 髓过氧化物酶MPO,作为一种白细胞酶,具有介导炎性反应、调节**应答等多种功能,并可参与**的发**展过程。同时,髓过氧化物酶基因存在基因多态性,也影响机体对**的易感性. 在正常**组织中和各种髓样细胞增生症中，MPO均有较强表达，如：**样细胞、原核细胞、肥大细胞、浆细胞以及各种上皮源性肿瘤和肉瘤等。
髓过氧化物酶抗中性粒细胞胞质IgG抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 激酶和磷酸酶 **细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid