成纤维细胞核受体Nr5a2抗体
规格：1mg/1ml
英文名： NR5A2
别名： NR5A2/LRH1; Alpha-1-fetoprotein transcription factor; B1-binding factor; B1F; B1F2; CPF; CYP7A promoter-binding factor; FTF; FTZ F1; FTZ F1beta; FTZ-F1; FTZ-F1beta; hB1F 2; HB1F; hB1F-2; Hepatocytic t
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human NR5A2
交叉反应：Human, Mouse, Rat, Chicken, Cow,
细胞定位：细胞核
成纤维细胞核受体Nr5a2抗体产品介绍：background: NR5A2 is a pre-adipocyte-specific nuclear receptor that regulates expression of aromatase in adipose tissue. NR5A2 belongs to the fushi tarazu factor-1 subfamily of orphan nuclear receptors. NR5A2 transcripts are abundant in the human ovary and testis and are predominantly expressed in tissues of endodermal origin. NR5A2 is a positive transcription factor for ABCG5 and ABCG8 and regulates genes involved in sterol and bile acid secretion from liver and intestine. It induces cell proliferation through the concomitant induction of cyclin D1 and E1, an effect that is potentiated by its interaction with beta-catenin. Function: Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for 成纤维细胞核受体Nr5a2抗体the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Subcellular Location: Nucleus. Tissue Specificity: Abundantly expressed in pancreas, less in liver, very low levels in heart and lung. Expressed in hepG2. Isoform 1 and isoform 2 seem to be present in fetal and ***** liver and hepG2 cells. Similarity: Belongs to the成纤维细胞核受体Nr5a2抗体 nuclear hormone receptor family. NR5 subfamily. Contains 1 nuclear receptor DNA-binding domain. Gene ID: 2494 Database links: Entrez Gene: 541305 Cow Entrez Gene: 2494 Human Entrez Gene: 26424 Mouse Entrez Gene: 60349 Rat Omim: 604453 Human SwissProt: O00482 Human SwissProt: P45448 Mouse SwissProt: Q9QWM1 Rat Unigene: 33446 Human Unigene: 16794 Mouse Unigene: 42941 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
成纤维细胞核受体Nr5a2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 发育生物学 染色质和核信号 微生物学 信号转导 干细胞 转录调节因子 **及病毒 细胞表面分子 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid