基质金属蛋白酶-24抗体
规格：1mg/1ml
英文名： MMP24
别名： Matrix metallopeptidase 24 (membrane inserted); Matrix metallopeptidase 24; Membrane type 5 matrix metalloproteinase; Membrane type matrix metalloproteinase 5; Membrane-type matrix metalloproteinase 5
分子量： 57kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MMP24
交叉反应：Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep,
细胞定位：细胞膜 分泌型蛋白
基质金属蛋白酶-24抗体产品介绍：background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than 基质金属蛋白酶-24抗体secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008] Function: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. Subcellular Location: Cell membrane; Single-pass type I membrane protein; Extracellular side. Processed matrix metalloproteinase-24: Secreted, extracellular space, extracellular matrix. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. Tissue Specificity: Expressed in基质金属蛋白酶-24抗体 brain. Expressed at low level in testis. Post-translational modifications: The precursor is cleaved by a furin endopeptidase. Similarity: Belongs to the peptidase M10A family. Contains 4 hemopexin-like domains. Gene ID: 10893 Database links: Entrez Gene: 10893 Human Entrez Gene: 83513 Rat Omim: 604871 Human SwissProt: Q9Y5R2 Human SwissProt: Q99PW6 Rat Unigene: 715494 Human Unigene: 3117 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
基质金属蛋白酶-24抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 神经生物学 信号转导 细胞粘附分子 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid