磷酸化磷脂酰肌醇激酶调节亚单位gamma抗体
规格：1mg/1ml
英文名： phospho-PI3-kinase regulatory subunit gamma (Tyr199)
别名： phospho-PI 3 Kinase p55 gamma (Tyr199); PI 3 Kinase p55 gamma (phospho Y199); PIK3R3; PI3-kinase regulatory subunit gamma (phospho Tyr199); P55G_HUMAN; Phosphatidylinositol 3-kinase regulatory subunit
分子量： 54kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human phospho-
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
磷酸化磷脂酰肌醇激酶调节亚单位gamma抗体产品介绍：background: The enzyme phosphatidylinositol 3 kinase (PI3 kinase) is a lipid kinase that generates phosphatidylinositol 3, 4, 5-triphosphate in response to receptor activation in many signal transduction pathways. Class IA PI3Ks exist as a heterodimer of a catalytic 110 kDa (p110) and a regulatory p85 subunit (e.g. p85 alpha). p85 alpha is an adaptor molecule that regulates the activity of the catalytic p110 subunit by binding to phosphorylated receptor tyrosine kinases (RTKs) through its SH2 domain and mediating the interaction between p110 and the plasma membrane. p85 alpha is necessary for insulin-stimulated increase in glucose 磷酸化磷脂酰肌醇激酶调节亚单位gamma抗体uptake and glycogen synthesis in insulin-sensitive tissues. Function: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. Subunit: Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL. Tissue Specificity: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Similarity: Belongs to the PI3K p85 subunit family.磷酸化磷脂酰肌醇激酶调节亚单位gamma抗体 Contains 2 SH2 domains. Gene ID: 8503 Database links: Entrez Gene: 8503 Human Entrez Gene: 18710 Mouse Entrez Gene: 60664 Rat Omim: 606076 Human SwissProt: Q92569 Human SwissProt: Q64143 Mouse SwissProt: Q63789 Rat Unigene: 170510 Human Unigene: 253819 Mouse Unigene: 44448 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化磷脂酰肌醇激酶调节亚单位gamma抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid