RAS相关GTP结合蛋白A抗体
规格：1mg/1ml
英文名： RRAGA + RRAGB
别名： FIP1; RAGA; FIP-1; RRAGB; Adenovirus E3 14.7 kDa-interacting protein 1; Rag A; RAg B; RagA; RAGB; Ras related GTP binding protein A; RRAGA_HUMAN; Ras-related GTP binding A； GTP-binding protein ragB; R
分子量： 37kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RRAGA an
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse, Sheep,
细胞定位：细胞核 细胞浆 细胞膜
RAS相关GTP结合蛋白A抗体产品介绍：background: Involved in the RCC1/Ran-GTPase pathway. RRAGA may play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. biquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. Function: Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. RAS相关GTP结合蛋白A抗体May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Subunit: Binds GTP. Can occur as a homodimer or as a heterodimer with RRAGC or RRAGD in a sequence-independent manner; heterodimerization stabilizes PPAG proteins. In complex with RRAGC, but not with RRAGB, interacts with RPTOR. The GTP-bound form of RRAGA interacts with NOL8. Interacts with adenovirus E3 14.7 kDa protein. Subcellular Location: Cytoplasm. Nucleus. Lysosome. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending oRAS相关GTP结合蛋白A抗体n the bound nucleotide state. Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane. Tissue Specificity: Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain. Similarity: Belongs to the GTR/RAG GTP-binding protein family. Gene ID: 10670 Database links: Entrez Gene: 10670 Human Entrez Gene: 68441 Mouse Entrez Gene: 117044 Rat Omim: 612194 Human SwissProt: Q7L523 Human SwissProt: Q80X95 Mouse SwissProt: Q63486 Rat Unigene: 702275 Human Unigene: 31178 Mouse Unigene: 2816 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
RAS相关GTP结合蛋白A抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 **学 染色质和核信号 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid