透明质酸结合蛋白2 27kDa轻链抗体抗体
规格：1mg/1ml
英文名： HABP2 27 kDa light chain
别名： Hyaluronan-binding protein 2 27 kDa light chain; Factor seven activating protease; Factor seven-activating protease; Factor VII activating protein; Factor VII-activating protease; FSAP; HABP 2; HABP;
分子量： 27kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Hyaluron
交叉反应：Human, Mouse, Rat, Horse, Rabbit,
细胞定位：分泌型蛋白
透明质酸结合蛋白2 27kDa轻链抗体抗体产品介绍：background: The protein encoded by this gene is an extracellular serine protease that binds hyaluronic acid and is involved in cell adhesion. The encoded protein is synthesized as a single chain, but then undergoes an autoproteolytic event to form the functional heterodimer. Further autoproteolysis leads to smaller, inactive peptides. This protease is known to cleave urinary plasminogen activator, coagulation factor VII, and the alpha and beta chains of fibrinogen, but not prothrombin, plasminogen, or the gamma chain of fibrinogen. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010] Function:透明质酸结合蛋白2 27kDa轻链抗体抗体 Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. Subunit: Heterodimer; disulfide-linked. Heterodimer of a 50 kDa heavy and a 27 kDa light chain linked by a disulfide bond. Subcellular Location: Secreted. Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. Tissue Specificity: Ubiquitously expressed. Post-translational modifications: Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain. The heavy chain can undergo further proteolytic cleavage at Lys-169 or Arg-170 to give 透明质酸结合蛋白2 27kDa轻链抗体抗体rise to 2 inactive 26 kDa fragments and the light chain can undergo further proteolytic cleavage at Arg-480 to give rise to inactive 17 kDa and 8 kDa fragments. Similarity: Belongs to the peptidase S1 family. Contains 3 EGF-like domains. Contains 1 kringle domain. Contains 1 peptidase S1 domain. Gene ID: 3026 Database links: Entrez Gene: 3026 Human Entrez Gene: 226243 Mouse Entrez Gene: 292126 Rat Omim: 603924 Human SwissProt: Q5E9Z2 Cow SwissProt: Q14520 Human SwissProt: Q8K0D2 Mouse SwissProt: Q6L711 Rat Unigene: 422542 Human Unigene: 25791 Mouse Unigene: 161908 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
透明质酸结合蛋白2 27kDa轻链抗体抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid