磷酸化泛素交联酶抗体
规格：1mg/1ml
英文名： Phosphor-UBE2s(Thr152)
别名： UBE2s(Phosphor T152); Phosphor-UBE2s(T152); E2 EPF; E2EPF; EPF5; UBE2S; Ubiquitin carrier protein S; Ubiquitin conjugating enzyme E2 24 kD; Ubiquitin conjugating enzyme E2S; Ubiquitin protein ligase S
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthesised phosphopeptide derived from human
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：
磷酸化泛素交联酶抗体产品介绍：background: This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008] Function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a磷酸化泛素交联酶抗体 E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination. Subunit: Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL. Post-translational modifications: Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome. Similarity: Belongs to the ubiquitin-conjugating enzyme family. Gene ID: 27338 磷酸化泛素交联酶抗体Database links: Entrez Gene: 617703 Cow Entrez Gene: 27338 Human Entrez Gene: 77891 Mouse Entrez Gene: 292588 Rat GenBank: NP_055316.2 Human Omim: 610309 Human SwissProt: Q1RML1 Cow SwissProt: Q16763 Human SwissProt: Q921J4 Mouse SwissProt: B5DFI8 Rat Unigene: 396393 Human Unigene: 389787 Mouse Unigene: 120398 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
磷酸化泛素交联酶抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid