肿瘤抑制基因NME2抗体
规格：1mg/1ml
英文名： Nm23-H2/NME2
别名： nucleoside dIPhosphatase kinase B; C myc purine binding transcription factor PUF; NDK B; NDKB; NDP kinase B; NDPKB; NM23 H2; NM23B; Nucleoside diphosphate kinase B; nm23-M2; NME2; Nucleoside diphospha
分子量： 17kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nm23
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
细胞定位：细胞核 细胞浆
肿瘤抑制基因NME2抗体产品介绍：background: NM23 is a heterodimeric protein functioning as a nucleoside diphosphate (NDP) kinase. NME1 and NME2 comprise the 152 amino acid A and B polypeptide chains of the NM23 enzyme, respectively. NME2 is identical to the beta subunit of human erythrocyte NDP kinase. NDP kinases are involved in the synthesis of nucleoside triphosphates, and NM23 may act in the regulation of signal transduction by complexing with G proteins, causing activation/inactivation of developmental pathways. NEM2 has been identified as a putative tumor suppressor. High expression of mouse NME2 is detected in heart, liver, and kidney, with moderate expression in肿瘤抑制基因NME2抗体 skeletal muscle, and negligible expression in other mouse tissues examined. Function: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. Subunit: Hexamer of two different chains: A and B (A6, A5B, A4B2, A3B3, A2B4, AB5, B6). Interacts with CAPN8. Interacts with AKAP13. Subcellular Location: Cytoplasm. Nucleus. Note=Isoform 2 is mainly cytoplasmic and isoform 1 and isoform 2 are excluded from the nucleolus. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the NDK family.肿瘤抑制基因NME2抗体 Gene ID: 4831 Database links: Entrez Gene: 395916 Chicken Entrez Gene: 480559 Dog Entrez Gene: 4831 Human Entrez Gene: 654364 Human Entrez Gene: 18103 Mouse Entrez Gene: 83782 Rat Omim: 156491 Human SwissProt: Q3T0Q4 Cow SwissProt: Q50KA8 Dog SwissProt: P22392 Human SwissProt: Q01768 Mouse SwissProt: Q2EN76 Pig SwissProt: P19804 Rat Unigene: 463456 Human Unigene: 1260 Mouse Unigene: 927 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Nm23-H2在高转移性的肿瘤中呈现低表达，提示NM23-H2具有转移抑制的功能。其抑制肿瘤转移机制为增强微丝、微管的聚合，影响细胞的移动，从而抑制肿瘤的侵袭和转移。
肿瘤抑制基因NME2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 转录调节因子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid