α -新内啡肽抗体
规格：1mg/1ml
英文名： Alpha neoendorphin
别名： prodynorphin; proenkephalin-B; Alpha neoendorphin; Alpha-neoendorphin; PDYN_HUMAN.
分子量： 1kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Alpha ne
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig,
细胞定位：分泌型蛋白
α -新内啡肽抗体产品介绍：background: The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]. Function: Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and α -新内啡肽抗体responses to stress. Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin. Leumorphin has a typical opiod activity and may have anti-apoptotic effect. Subcellular Location: Secreted. Post-translational modifications: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. DISEASE: Defects in PDYN are the cause of spinocerebellar ataxia type 23 (SCA23) [MIM:610245]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of handsα -新内啡肽抗体, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA23 is an *****-onset autosomal dominant form characterized by slowly progressive gait and limb ataxia, with variable additional features, including peripheral neuropathy and dysarthria. Similarity: Belongs to the opioid neuropeptide precursor family. Gene ID: 5173 Database links: Entrez Gene: 5173 Human Entrez Gene: 18610 Mouse Entrez Gene: 29190 Rat Omim: 131340 Human SwissProt: Q95104 Cow SwissProt: P01213 Human SwissProt: O35417 Mouse SwissProt: P06300 Rat Unigene: 22584 Human Unigene: 44471 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
α -新内啡肽抗体产品应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 ***病
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid