轴突导向受体蛋白3抗体
规格：1mg/1ml
英文名： Robo3
别名： HGPPS; HGPS; RB inhibiting gene 1; Rbig 1; Rbig1; Retinoblastoma inhibiting gene 1; Rig 1; Rig1; Robo 3; Robo3; Robo3 protein; ROBO3_HUMAN; Roundabout axon guidance receptor homolog 3; Roundabout homo
分子量： 146kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Robo3
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse,
细胞定位：细胞膜 分泌型蛋白
轴突导向受体蛋白3抗体产品介绍：background: This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure轴突导向受体蛋白3抗体 of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated. Function: Thought to be involved during neural development in axonal navigation at the ventral midline of the neural tube. In spinal chord development plays a role in guiding commissural axons probably by preventing premature sensitivity to Slit proteins thus inhibiting Slit signaling through ROBO1. Required for hindbrain axon midline crossing. Subcellular Location: Membrane; Single-pass type I membrane protein DISEASE: Defects in ROBO3 are a cause of familial horizontal gaze palsy with progressive scoliosis (HGPPS) [MIM:607313]. Patients show a medulla where motor and sensory projections appear uncrossed. Similarity: Belongs to the immunoglobulin superfamily. ROBO family. Contains 3 fibronectin type-III domains. Contains 5 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 64221 Database links: Entrez Gene: 489307 轴突导向受体蛋白3抗体Dog Entrez Gene: 100072287 Horse Entrez Gene: 64221 Human Entrez Gene: 19649 Mouse Entrez Gene: 30770 Zebrafish Omim: 608630 Human SwissProt: Q96MS0 Human SwissProt: Q9Z2I4 Mouse Unigene: 435621 Human Unigene: 212826 Mouse Entrez Gene: 712 Human Entrez Gene: 713 Human Entrez Gene: 714 Human Entrez Gene: 12259 Mouse Entrez Gene: 12260 Mouse Entrez Gene: 12262 Mouse Entrez Gene: 29687 Rat Entrez Gene: 298566 Rat Entrez Gene: 362634 Rat Omim: 120550 Human Omim: 120570 Human Omim: 120575 Human SwissProt: P02745 Human SwissProt: P02746 Human SwissProt: P02747 Human SwissProt: P14106 Mouse SwissProt: P98086 Mouse SwissProt: Q02105 Mouse SwissProt: P31720 Rat SwissProt: P31721 Rat SwissProt: P31722 Rat Unigene: 632379 Human Unigene: 439957 Mouse Unigene: 105647 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
轴突导向受体蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 神经生物学 细胞膜受体
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid