补体C1qα链多肽抗体
规格：1mg/1ml
英文名： C1Q
别名： C1QA; C1QA_HUMAN; C1QB; C1QC; Complement C1q subcomponent subunit A; Complement C1q subcomponent subunit B; Complement C1q subcomponent subunit C; Complement component 1 q subcomponent A chain; Comple
分子量： 24kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human C1Q
交叉反应：Human,
细胞定位：分泌型蛋白
补体C1qα链多肽抗体产品介绍：background: C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. However, its ability to modulate the interaction of platelets with collagen and immune complexes suggests C1q influences homeostasis as补体C1qα链多肽抗体 well as other immune activities, and perhaps thrombotic complications resulting from immune injury. Defects in C1q-A, C1q-B and C1q-C cause inactivation of the classical pathway, leading to a rare genetic disorder characterized by lupus-like symptoms. Function: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Subunit: C1 is a calcium-dependent trimolecular complex of C1q, R and S in the molar ration of 1:2:2. C1q subcomponent is composed of nine subunits, six of which are disulfide-linked dimers of the A and B chains, and three of which are disulfide-linked dimers of the C chain. Subcellular Location: Secreted. Post-translational modifications: O-linked glycans consist of 补体C1qα链多肽抗体Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. Similarity: Contains 1 C1q domain. Contains 1 collagen-like domain. Gene ID: 712 Database links: Entrez Gene: 712 Human Entrez Gene: 713 Human Entrez Gene: 714 Human Entrez Gene: 12259 Mouse Entrez Gene: 12260 Mouse Entrez Gene: 12262 Mouse Entrez Gene: 29687 Rat Entrez Gene: 298566 Rat Entrez Gene: 362634 Rat Omim: 120550 Human Omim: 120570 Human Omim: 120575 Human SwissProt: P02745 Human SwissProt: P02746 Human SwissProt: P02747 Human SwissProt: P14106 Mouse SwissProt: P98086 Mouse SwissProt: Q02105 Mouse SwissProt: P31720 Rat SwissProt: P31721 Rat SwissProt: P31722 Rat Unigene: 632379 Human Unigene: 439957 Mouse Unigene: 105647 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
补体C1qα链多肽抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：**学 神经生物学 细胞类型标志物
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid