尿路上皮特异蛋白1a抗体
规格：1mg/1ml
英文名： Uroplakin Ia
别名：
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Uroplaki
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞膜
尿路上皮特异蛋白1a抗体产品介绍：background: The asymmetric unit membrane (AUM) forms numerous plaques, which cover the apical surface of the urothelium. These plaques are thought to strengthen the urothelium and reduce the risk of rupturing during ladder distention. They are composed of four major integral membrane proteins called uroplakins (UP). The uroplakin family comprises UPIa, UPIb, UPII, and UPIII. Family members are conserved among several species, including human, mouse, rat, rabbit, dog, pig and sheep. UPIa and UPIb form tightly packed structures with UPII and UPIII, respectively. This pairing is required for normal urothelial plaque formation and is regulated by proteolytic processing of the uroplakin proteins. Uroplakins are expressed in normal urothelium and are used as specific markers of urothelial differentiation.尿路上皮特异蛋白1a抗体 They are also expressed in a majority of transitional cell carcinomas of the bladder (TCCs), which make the uroplakins a useful marker for detecting bladder cancer metastasis and for staging and monitoring chemotherapeutic response. Function: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. Subunit: Homodimer; disulfide-linked. Interacts with uroplakin-2 (UPK2). Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate. Expression in normal 尿路上皮特异蛋白1a抗体urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies. Similarity: Belongs to the tetraspanin (TM4SF) family. Gene ID: 11045 Database links: Entrez Gene: 11045 Human Omim: 611557 Human SwissProt: O00322 Human SwissProt: Q3KNU5 Human SwissProt: Q3KNU6 Human Unigene: 159309 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
尿路上皮特异蛋白1a抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 信号转导
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid