视锥感光细胞环磷酸鸟苷门控通道蛋白CNG3抗体
规格：1mg/1ml
英文名： CNG3
别名： ACHM2; CCNC1; CCNCa; CCNCalpha; CNCG3; CNG 3; CNG-3; CNG channel alpha 3; CNG channel alpha-3; CNG-3; CNG3; CNGA3; Cnga3 cyclic nucleotide gated channel alpha 3; CNGA3_HUMAN; Cone photoreceptor cGMP g
分子量： 79kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CNG3
交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Sheep, Guinea Pig,
细胞定位：细胞膜
视锥感光细胞环磷酸鸟苷门控通道蛋白CNG3抗体产品介绍：background: Cyclic nucleotide-gated (CNG) cation channels are heteromeric complexes made up of principal alpha and modulatory beta subunits. The alpha subunits consist of CNG1-3 and form functional cation channels by themselves. The beta subunits consist of CNG4-6 and, unlike the alpha subunits, do not form functional channels, but rather modify the properties of channels. CNG channels are essential components of olfactory and visual transduction. In olfactory neurons, CNG2, CNG4.3 and CNG5 form Ca2+ permeable channels, which open and depolarize the cell in response to cAMP. In rod photoreceptors, CNG1 and CNG4.1 combine to form Ca ion permeable channels, which give rise to a current in response to cGMP. CNG3 and CNG6 are expressed in cone receptors and may combine to form a native cGMP-activated channel. CNG channels have been implicated in other areas. CNG1 is also expressed in medium-sized and 视锥感光细胞环磷酸鸟苷门控通道蛋白CNG3抗体small-sized arteries, suggesting a role for CNG in the regulation of arterial blood pressure and of blood supply to different regions. CNG1, CNG4.1 and CNG4.2 have been detected in the rat pineal gland. CNG2, CNG4.3 and CNG5 are present in GT1 cell lines and may play a role in the secretion of gonadotropin-releasing hormone. Function: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. Subunit: Tetramer formed of two视锥感光细胞环磷酸鸟苷门控通道蛋白CNG3抗体 CNGA3 and two CNGB3 modulatory subunits. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Prominently expressed in retina. Post-translational modifications: Defects in CNGA3 are the cause of achromatopsia type 2 (ACHM2) [MIM:216900]; also known as total colorblindness or rod monochromacy (RMCH2). ACHM2 is an autosomal recessive condition characterized by day blindness and photophobia. In ACHM2 patients the cones are defective and the subjects see better at night. Similarity: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA3 subfamily. Contains 1 cyclic nucleotide-binding domain. Gene ID: 1261 Database links: Entrez Gene: 1261 Human Omim: 600053 Human SwissProt: Q16281 Human Unigene: 234785 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
视锥感光细胞环磷酸鸟苷门控通道蛋白CNG3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid