**样物质结合蛋白/细胞粘附分子样蛋白抗体
规格：1mg/1ml
英文名： OPCML
别名： opioid binding protein/cell adhesion molecule-like; OPCML; OBCAM; OPCM; 3732419F12; C230027C17; 2900075O15RIK; AI844366; B930023M13RIK; Gm181; IGLON1; MGC99974; OPCM_HUMAN; Opioid-binding protein/cell
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human OPCML
交叉反应：Human, Mouse, Rat, Chicken, Cow, Horse, Rabbit,
细胞定位：细胞膜
**样物质结合蛋白/细胞粘附分子样蛋白抗体产品介绍：background: This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms**样物质结合蛋白/细胞粘附分子样蛋白抗体 have been found for this gene. [provided by RefSeq] Function: Binds opioids in the presence of acidic lipids; probably involved in cell contact. Subcellular Location: Cell membrane. DISEASE: Defects in OPCML are a cause of susceptibility to ovarian cancer (OC) [MIM:167000]. Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized**样物质结合蛋白/细胞粘附分子样蛋白抗体 signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease. Similarity: Belongs to the immunoglobulin superfamily. IgLON family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 4978 Database links: Entrez Gene: 4978 Human Omim: 600632 Human SwissProt: Q14982 Human Unigene: 4817 Human Unigene: 720580 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. OPCML基因的作用是产生一种能帮助卵巢表面分子粘合在一起的蛋白质，当这一基因关闭后，细胞间的粘合力减弱，此时如细胞加速生长，即有可能产生早期癌变。 经研究发现，OPCML能够增加细胞的黏附能力,抑制癌细胞的增殖,OPCML可能是一个新的抑癌基因.在早期病症中能抑制癌变细胞蛋白质的生成，并有效阻止癌变细胞的生长。
**样物质结合蛋白/细胞粘附分子样蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 **学 细胞粘附分子
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid