肝癌高表达基因抗体

肝癌高表达基因抗体

规格：1mg/1ml

英文名： PEG10

别名： Paternally expressed gene 10; MyEF 3; AA407948; Edr; Embryonal carcinoma differentiation regulated; HB 1; HB1; KIAA1051; Mar2; Mart2; MEF3 like 1; MEF3L; MEF3L1; Paternally expressed 10; Paternally ex

分子量： 78kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human PEG10 (3

交叉反应：Human, Mouse, Rat, Dog, Pig, Cow,

细胞定位：细胞核 细胞浆

肝癌高表达基因抗体产品介绍：background: This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. [provided by RefSeq, May 2010]. Function: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension,肝癌高表达基因抗体 such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter. Subunit: Interacts with ALK1, SIAH1 and SIAH2. Subcellular Location: Nucleus. Cytoplasm. Note=Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1. Tissue Specificity: Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the HepG2 cell line (at protein level). Expressed in brain, liver, spleen, kidney肝癌高表达基因抗体, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC). Post-translational modifications: Isoform RF1/RF2 undergoes proteolytic cleavage. Similarity: Contains 1 CCHC-type zinc finger. Gene ID: 2389 Database links: Entrez Gene: 23089 Human Entrez Gene: 170676 Mouse Entrez Gene: 654416 Pig Omim: 609810 Human SwissProt: Q86TG7 Human SwissProt: Q7TN75 Mouse Unigene: 147492 Human Unigene: 320575 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PEG10是一个癌基因,在肿瘤癌变过程中起重要作用。PEG10在原发性肝癌中表达明显上调，体外细胞试验证明PEG10影响细胞周期，可促进细胞生长，在肝细胞癌变过程中起重要作用。

肝癌高表达基因抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  细胞生物  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid

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