血管生成素3/血管生成素4抗体
规格：1mg/1ml
英文名： Angiopoietin 4
别名： Angiopoietin 4; AGP4; ANG3; ANG-4; ANG 4; ANGPT4; AGP4; ANGP4_HUMAN. ANG 3; ANG-3; ANG3; Angioarrestin; Angiopoietin 3; Angiopoietin like 1; Angiopoietin like protein 1; Angiopoietin related protein 1
分子量： 54kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ANGPT4 C
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：分泌型蛋白
血管生成素3/血管生成素4抗体产品介绍：background: Angiopoietin 4 is a glycosylated protein with a fibrinogen C terminal domain. It is induced under hypoxic conditions in endothelial cells and is the target of peroxisome proliferation activators. Angiopoietin 4 is a serum hormone directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity and also acts as an apoptosis survival factor for vascular endothelial cells. It may play a role in several cancers and it also has been shown to prevent the metastatic process 血管生成素3/血管生成素4抗体by inhibiting vascular activity as well as tumor cell motility and invasiveness. Decreased expression of this protein has been associated with type 2 diabetes. Alternatively spliced transcript variants encoding different isoforms have been described Function: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival,血管生成素3/血管生成素4抗体 migration and angiogenesis. Subunit: Homodimer; disulfide-linked. Interacts with TEK/TIE2. Subcellular Location: Secreted (Probable). Tissue Specificity: Highly expressed in the lung with much lower levels found in other tissues. Similarity: Contains 1 fibrinogen C-terminal domain. Gene ID: 51378 Database links: Entrez Gene: 51378 Human Omim: 603705 Human SwissProt: Q9Y264 Human Unigene: 278973 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 血管生成素4-ANGPTL4与小血管生成、肿瘤的转移有很重要的关系。
血管生成素3/血管生成素4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 心血管 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid