多药耐药相关蛋白2抗体
规格：1mg/1ml
英文名： MRP2/ABCC2
别名： multidrug resistance-associated protein2; ABC30; ABCC2; ATP binding cassette sub family C (CFTR/MRP) member 2; ATP binding cassette subfamily C member 2; Canalicular multidrug resistance protein; Cana
分子量： 174kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MRP2 (48
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
多药耐药相关蛋白2抗体产品介绍：background: multidrug resistance-associated protein 2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by 多药耐药相关蛋白2抗体conjugated hyperbilirubinemia. Belongs to the ABC transporter family. Function: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver. DISEASE: Defects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia,多药耐药相关蛋白2抗体 an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. Similarity: Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. Contains 2 ABC transmembrane type-1 domains. Contains 2 ABC transporter domains. Gene ID: 1244 Database links: Entrez Gene: 1244 Human Entrez Gene: 12780 Mouse Entrez Gene: 25303 Rat Omim: 601107 Human SwissProt: Q92887 Human SwissProt: Q8VI47 Mouse SwissProt: Q63120 Rat Unigene: 368243 Human Unigene: 39054 Mouse Unigene: 10265 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. MRP-2作为一种结合输出泵，转运许多不同的**结合物的蛋白。 MRP2蛋白的染色阳性产物分布于细胞浆/膜中。
多药耐药相关蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid