CDC42结合蛋白激酶α/MRCKα抗体
规格：1mg/1ml
英文名： MRCK alpha
别名： CDC42 binding protein kinase alpha; CDC42 binding protein kinase alpha (DMPK like); CDC42 binding protein kinase alpha; CDC42 binding protein kinase alpha dmpk like; CDC42 binding protein kinase beta;
分子量： 197kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MRCK alp
交叉反应：Human, Mouse, Rat, Horse, Rabbit,
细胞定位：细胞浆 细胞膜
CDC42结合蛋白激酶α/MRCKα抗体产品介绍：background: The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq, Jul 2008] Function: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation. Subunit: Homodimer and homotetramer via the coiled coil regions. Interacts tightly withCDC42结合蛋白激酶α/MRCKα抗体 GTP-bound but not GDP-bound CDC42. Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPA and MYO18A. LURAP1 binding results in activation of CDC42BPA by abolition of its negative autoregulation. Subcellular Location: Cytoplasm. Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent. Tissue Specificity: Abundant in the heart, brain, skeletal muscle, kidney, and pancreas, with little or no expression in the lung and liver. Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 CNH domain. Contains 1 CRIB domain. Contains 1 PH domain. Contains CDC42结合蛋白激酶α/MRCKα抗体1 phorbol-ester/DAG-type zinc finger. Contains 1 protein kinase domain. Gene ID: 8476 Database links: Entrez Gene: 8476 Human Entrez Gene: 226751 Mouse Entrez Gene: 114116 Rat GenBank: NP_003598 Human GenBank: NP_055641 Human Omim: 603412 Human SwissProt: Q5VT25 Human SwissProt: Q3UU96 Mouse SwissProt: O54874 Rat Unigene: 35433 Human Unigene: 259655 Mouse Unigene: 10871 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CDC42结合蛋白激酶α/MRCKα抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：信号转导 激酶和磷酸酶 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid