Iroquois同源蛋白4抗体
规格：1mg/1ml
英文名： IRX4
别名： Homeodomain protein IRXA3; Iroquois Homeobox Protein 4; Iroquois-class homeodomain protein IRX-4; Iroquoisclass homeodomain protein IRX4; Irx4; IRX4_HUMAN; IRXA3.
分子量： 54kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IRX4
交叉反应：Human, Mouse, Rat, Chicken, Dog, Horse,
细胞定位：细胞核
Iroquois同源蛋白4抗体产品介绍：background: The Iroquois homeobox gene family of transcription factors regulate aspects of embryonic development including anterior/posterior and dorsal/ventral axis patterning in the central nervous system. The Iroquois family are clustered on two loci, IRXA and IRXB, which map to chromosomes 8 and 13 in mice. The IRXA group includes Irx1, Irx2 and Irx4; the IRXB group is comprised of Irx3, Irx5 and Irx6. Irx1 and Irx2 are both widely expressed during development in the lung epithelium and also in the ventricular septum. Irx1 and Irx2 also play a role in digit formation (E11.5–E14.5). The Irx gene family members are each expressed in a distinct pattern during mouse heart development. Specifically, Irx1 and Irx2 are expressed in the ventricular septum and Irx3 is expressed in the ventricular trabeculated myocardium. In addition, Irx4 is expressed in the linear heart tube and the AV canal, and Irx5 is expressed in the endocardium lining the Iroquois同源蛋白4抗体ventricular and atrial myocardium. Furthermore, the IRX4 gene may modulate cardiac development and function. Although the heart of Irx4(-) mice appears to develop normally, ***** Irx4(-) mice exhibit cardiomyopathy, including cardiac hypertrophy and decreased contractility. Function: Likely to be an important mediator of ventricular differentiation during cardiac development. Subcellular Location: Nucleus. Tissue Specificity: Predominantly expressed in cardiac ventricles. Similarity: Belongs to the TALE/IRO homeobox family. Contains 1 homeobox DNA-binding Iroquois同源蛋白4抗体domain. Database links: Entrez Gene: 50805 Human Entrez Gene: 50916 Mouse Entrez Gene: 306655 Rat Omim: 606199 Human SwissProt: P78413 Human SwissProt: Q2NL64 Human SwissProt: A0JNT5 Mouse SwissProt: Q3V1B6 Mouse SwissProt: Q9QY61 Mouse Unigene: 196927 Human Unigene: 103784 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Iroquois同源蛋白4抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 发育生物学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid