神经管畸形相关蛋白VANGL2抗体
规格：1mg/1ml
英文名： VANGL2
别名： Homolog of Drosophila strabismus; KIAA1215; Loop tail associated protein; loop tail protein 1 homolog; Loop-tail protein 1 homolog; LPP 1; LPP1; LTAP; STB 1; STB1; STBM 1; STBM; STBM1; Strabismus 1; v
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human VANGL2
交叉反应：Human, Mouse, Rat, Dog, Cow, Sheep,
细胞定位：细胞膜
神经管畸形相关蛋白VANGL2抗体产品介绍：background: The Vang family of proteins are integral membrane proteins that are homologs of the Drosophila tissue polarity gene strabismus. The gene encoding for Van Gogh-like protein 1 (Vangl1), also designated Strabismus 2 (STB2), localizes to chromosome 1p11-p13.1. Van Gogh-like protein 2 (Vangl2), also designated Strabismus1 (STB1), localizes on chromosome 1q22-q23. Vangl1 is expressed in testis and ovary, but also in gastric and pancreatic cancer. Vangl proteins play a key developmental role in establishing planar cell polarity (PCP) and in regulating convergent extension (CE) movements during embryogenesis. Vangl1 and Vangl2 are both down-regulated in several cancer cell lines and primary tumors. Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Function: Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization神经管畸形相关蛋白VANGL2抗体 and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process (By similarity). Subunit: Interacts through its C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3. The PDZ domain of DVL1, DVL2 and DVL3 is required for the interaction. Also interacts with the PDZ domains of MAGI3, SCRIB/SCRB1 and FZD3 (By similarity). Subcellular Location: Membrane; Multi-pass membrane protein (Potential). DISEASE: Defects in VANGL2 are a cause of neural tube defects (NTD) [MIM:182940]. NTD are congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele神经管畸形相关蛋白VANGL2抗体 and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. Similarity: Belongs to the Vang family. Gene ID: 57216 Database links: Entrez Gene: 57216 Human Entrez Gene: 93840 Mouse Entrez Gene: 289229 Rat Omim: 600533 Human SwissProt: Q9ULK5 Human SwissProt: Q91ZD4 Mouse SwissProt: P84889 Rat Unigene: 99477 Human Unigene: 36148 Mouse Unigene: 392110 Mouse Unigene: 198958 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
神经管畸形相关蛋白VANGL2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 发育生物学 神经生物学 干细胞
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid