DVL3蛋白抗体
规格：1mg/1ml
英文名： Dishevelled 3
别名： Segment polarity protein dishevelled homolog DVL 3; Dishevelled 3 (homologous to Drosophila dsh); Dishevelled 3; Dishevelled 3, dsh homolog (Drosophila); Dishevelled, dsh homolog 3 (Drosophila); Dishe
分子量： 78kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Dishevel
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep,
细胞定位：细胞浆
DVL3蛋白抗体产品介绍：background: Mammalian homologs of the Drosophila dishevelled (Dsh) gene have been identified, including Dvl-1, Dvl-2 and Dvl-3. The mammalian dishevelled proteins contain three homologous domains, two of which are unrelated to any other known protein. The third region is homologous to the discs-large homology domain of Drosophila discs-large-1, a tumor suppressor protein. Like their Drosophila counterpart, the dishevelled proteins are thought to be in-volved in embryogenesis. Overexpression of Dvl-1 has been shown to inhibit the phosphorylation of tau by GSK-3b. This finding may prove to be important in Alzheimer’s studies, which have shown that tau is hyperphosphorylated. In Drosophila, Dsh is a component of the frizzled signaling pathway. Both mammalian dishevelled and frizzled proteins are components of the Wnt signalling pathway. Function: May play a role in the signal transduction pathway mediated by multiple Wnt genes. Subunit: InteractsDVL3蛋白抗体 (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2 (By similarity). Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD, CEP164 and DAB2. Subcellular Location: Cytoplasm. Post-translational modifications: Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains. Phosphorylated by CSNK1D. Similarity: Belongs to the DSH family. Contains 1 DEP domain. Contains 1 DIX domain. Contains 1 PDZ (DHR) domain. Database links: Entrez Gene:DVL3蛋白抗体 1857 Human Entrez Gene: 13544 Mouse Entrez Gene: 303811 Rat Omim: 601368 Human SwissProt: Q92997 Human SwissProt: Q61062 Mouse Unigene: 388116 Human Unigene: 247259 Mouse Unigene: 272443 Mouse Unigene: 219497 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
DVL3蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 神经生物学 信号转导 细胞凋亡
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid