肌动蛋白结合蛋白Z盘状蛋白抗体
规格：1mg/1ml
英文名： Nebulette
别名： Actin binding Z disk protein; bA56H7.1; LIM nebulette; LNEBL; NEBL; NEBL_HUMAN.
分子量： 116kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Nebulett
交叉反应：Human, Mouse, Rat,
细胞定位：细胞浆
肌动蛋白结合蛋白Z盘状蛋白抗体产品介绍：background: Nebulette binds to actin and plays an important role in Z-disk assembly. It is a cardiac homolog of nebulin and its expression is abundant in cardiac muscle. Nebulette defects are assocated with non-familial idiopathic cardiacmyopathy. Nebulin and nebulette are homologous thin-filament associated proteins expressed in skeletal and cardiac muscles, respectively. Nebulette, unlike nebulin, is confined to the Z-disc region of the sarcomere and does not span the whole thin filament length. Nebulette colocalizes with α-actinin in the pre-, nascent, and mature myofibrils. A polymorphism in the actin-binding motif of nebulette is a genetic marker of susceptibility to nonfamilial idiopathic dilated cardiomyopathy (IDC), characterized by a thin-walled heart and systolic dysfunction. Function:肌动蛋白结合蛋白Z盘状蛋白抗体 Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion. Subunit: Isoform 2 interacts with ZYX (Zyxin). Subcellular Location: Cytoplasmic. Tissue Specificity: Abundantly expressed in cardiac muscle, but not in skeletal or smooth muscle. Localized to Z-lines in cardiac cells and to dense bodies in nonmuscle cells. Isoform 2 肌动蛋白结合蛋白Z盘状蛋白抗体is expressed in non-muscle cells such as in fibroblasts. Similarity: Contains 23 nebulin repeats. Contains 1 SH3 domain. Gene ID: 10529 Database links: Entrez Gene: 10529 Human Entrez Gene: 74103 Mouse Omim: 605491 Human SwissProt: O76041 Human SwissProt: Q9DC07 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌动蛋白结合蛋白Z盘状蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：心血管 信号转导 结合蛋白 细胞骨架
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid