T细胞急性**细胞性白血病1蛋白/**瘤蛋白5抗体
规格：1mg/1ml
英文名： Tal1
别名： bHLHa17; Class A basic helix-loop-helix protein 17; SCL antibody; Stem cell protein; T cell acute lymphocytic leukemia 1; T cell acute lymphocytic leukemia 1 protein; T cell leukemia/lymphoma 5 protei
分子量： 34kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Tal1
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核
T细胞急性**细胞性白血病1蛋白/**瘤蛋白5抗体产品介绍：background: Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors. Function: Implicated in the genesis of hemopoietic malignancies.T细胞急性**细胞性白血病1蛋白/**瘤蛋白5抗体 It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Subcellular Location: Nucleus. Tissue Specificity: Leukemic stem cell. SimilarityT细胞急性**细胞性白血病1蛋白/**瘤蛋白5抗体: Contains 1 basic helix-loop-helix (bHLH) domain. Gene ID: 6886 Database links: Entrez Gene: 6886 Human Omim: 187040 Human SwissProt: P17542 Human Unigene: 705618 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
T细胞急性**细胞性白血病1蛋白/**瘤蛋白5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 发育生物学 信号转导 干细胞 细胞周期蛋白 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid