环指蛋白27抗体
规格：1mg/1ml
英文名： GERP
别名： RNF27; Lioblastoma expressed ring finger protein; Ring finger protein 27; RNF27; RP11-47A8.4; TRIM8; Tripartite motif containing 8; Tripartite motif protein TRIM8; TRIM8_HUMAN.
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human GERP/TRI
交叉反应：Human, Mouse, Rat, Chicken, Dog, Horse, Sheep,
细胞定位：
环指蛋白27抗体产品介绍：background: The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM8 (tripartite motif containing 8), also known as GERP (glioblastoma-expressed RING finger protein) or RNF27 (RING finger protein 27), is a 551 amino acid protein that is thought to function as an E3 ubiquitin-protein ligase that promotes SOCS-1 proteasomal degradation. As a widely expressed homodimer, TRIM8 localizes to nuclear bodies and contains two B box-type zinc fingers and one RING-type zinc finger. TRIM8 is expressed in lung, heart,环指蛋白27抗体 brain and skeletal muscle, with low levels detected in intestine, placenta, leukocytes and liver. The gene encoding TRIM8 maps to human chromosome 10q24.32. Function: Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1 (By similarity). Subunit: Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box (By similarity). Tissue Specificity: Widely expressed. Similarity: Belongs to the TRIM/RBCC family. Contains 2 B box-type zinc fingers. Contains 1 RING-type zinc finger. Gene ID: 81603 Database links: Entrez Gene: 环指蛋白27抗体81603 Human Entrez Gene: 93679 Mouse Entrez Gene: 688785 Rat Omim: 606125 Human SwissProt: Q9BZR9 Human SwissProt: Q99PJ2 Mouse Unigene: 336810 Human Unigene: 392177 Mouse Unigene: 481672 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白27抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 锌指蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid