肌肉特异性环指蛋白2抗体
规格：1mg/1ml
英文名： MURF2
别名： MURF 2; MURF-2; MuRF2; Muscle specific ring finger 2; Muscle specific RING finger protein 2; Muscle-specific RING finger protein 2; ring finger protein 29; RNF 29; RNF29; TRI55_HUMAN; TRIM 55; Trim55;
分子量： 60kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MURF2
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞浆
肌肉特异性环指蛋白2抗体产品介绍：background: MuRF1 (RNF28), MuRF2 (RNF29) and MuRF3 (RNF30) are a specific class of RING finger proteins expressed in striated muscle tissues that act as signaling molecules and cytoskeletal adaptors. The MuRF proteins contain a conserved N-terminal RING domain and zinc-binding B-box motif in addition to two coiled-coil motifs in their central regions. In muscle cells, MuRF2 regulates gene expression and protein turnover. It localizes to the cytoplasm, but under atrophic conditions it is detected in the nucleus. MuRF2 can form oligomers with various other proteins, including titin and myosin, during sarcomere assembly. Endogenous MuRF2 associates with the sarcomeric M-band in cardiomyocytes. There are at least four isoforms of MuRF2. Subunit: Homooligomer and heterooligomer (Probable). 肌肉特异性环指蛋白2抗体Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54. Subcellular Location: Cytoplasm. Nucleus. Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules. 肌肉特异性环指蛋白2抗体Tissue Specificity: Highly expressed in muscle. Low-level expression in liver. Similarity: Contains 1 B box-type zinc finger. Contains 1 COS domain. Contains 1 RING-type zinc finger. Gene ID: 84675 Database links: Entrez Gene: 84675 Human Entrez Gene: 381485 Mouse Entrez Gene: 365751 Rat Omim: 606469 Human SwissProt: Q9BYV6 Human SwissProt: Q5PQN5 Rat Unigene: 85524 Human Unigene: 35419 Mouse Unigene: 76142 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
肌肉特异性环指蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid