膜相关环指蛋白9抗体
规格：1mg/1ml
英文名： 42438
别名： E3 ubiquitin protein ligase MARCH9; MARCH IX; Membrane associated RING CH protein IX; membrane associated ring finger (C3HC4) 9; Membrane associated RING finger protein 9; RING finger protein 179; RNF
分子量： 38kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MARCH9
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
膜相关环指蛋白9抗体产品介绍：background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH9 (membrane-associated ring finger (C3HC4) 9), also known as RNF179, is a 346 amino acid multi-pass membrane protein that localizes to the golgi apparatus and contains one RING-CH-type zinc finger. Expressed ubiquitously, MARCH9 exists as a homodimer and functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to promote the degradation of target proteins, such as CD4 膜相关环指蛋白9抗体and MHC-I. Multiple isoforms of MARCH9 exist due to alternative splicing events. Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Subunit: Homodimer. Subcellular Location: Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; 膜相关环指蛋白9抗体Multi-pass membrane protein. Tissue Specificity: Ubiquitously expressed. Similarity: Contains 1 RING-CH-type zinc finger. Gene ID: 92979 Database links: Entrez Gene: 92979 Human Omim: 613336 Human SwissProt: Q86YJ5 Human Unigene: 632709 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产膜相关环指蛋白9抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-F=1:100-500 Flow-Cyt=1:20-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid