蛋白酶体PSMD3抗体
规格：1mg/1ml
英文名： Proteasome 26S S3
别名： 26S proteasome non ATPase regulatory subunit 3; 26S proteasome non-ATPase regulatory subunit 3; 26S proteasome regulatory subunit RPN3; 26S proteasome regulatory subunit S3; P58; Proteasome (prosome,
分子量： 61kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Proteaso
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
细胞定位：细胞浆
产蛋白酶体PSMD3抗体品介绍：background: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Function: Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Subunit: The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Subcellular Location:蛋白酶体PSMD3抗体 Cytoplasm. Similarity: Belongs to the proteasome subunit S3 family. Contains 1 PCI domain. Gene ID: 5709 Database links: Entrez Gene: 5709 Human Entrez Gene: 22123 Mouse Entrez Gene: 287670 Rat SwissProt: Q2KJ46 Cow SwissProt: O43242 Human SwissProt: P14685 Mouse Unigene: 12970 Human Unigene: 12194 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. (proteasomes)蛋白酶体的主要作用是降解细胞不需要的或受到损伤的蛋白质，这一作用是通过打断肽键的化学反应来实现。能够发挥这一作用的酶被称为蛋白酶。蛋白酶体是细胞用来调控特定蛋白质和除去错误折叠蛋白质的主要机制。经过蛋白酶体的降解蛋白酶体PSMD3抗体，蛋白质被切割为约7-8个氨基酸长的肽段；这些肽段可以被进一步降解为单个氨基酸分子，然后被用于合成新的蛋白质。需要被降解的蛋白质会先被一个称为泛素的小型蛋白质所标记（即连接上）。这一标记反应是被泛素连接酶所催化。一旦一个蛋白质被标记上一个泛素分子，就会引发其它连接酶加上更多的泛素分子；这就形成了可以与蛋白酶体结合的“多泛素链”，从而将蛋白酶体带到这一标记的蛋白质上，开始其降解过程。 蛋白酶体降解途径对于许多细胞进程，包括细胞周期、基因表达的调控、氧化应激反应蛋白酶体PSMD3抗体等，都是必不可少的。
产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid