蛋白酶体PSMα3抗体
规格：1mg/1ml
英文名： Proteasome 20S alpha 3
别名： 20S Proteasome α3; HC8; Macropain subunit C8; Multicatalytic endopeptidase complex subunit C8; Proteasome (prosome macropain) subunit alpha type 3; Proteasome alpha 3 subunit; Proteasome component C8;
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Proteaso
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit,
细胞定位：细胞核 细胞浆
蛋白酶体PSMα3抗体产品介绍：background: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting 蛋白酶体PSMα3抗体in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with AURKB. Interacts with CDKN1A. Interacts with HIV-1 TAT protein. Interacts with hepatitis C virus (HCV) F protein. Interacts with Epstein-Barr virus EBNA3 proteins. Interacts with MDM2 and RB1. Interacts with the C-terminus of TBXA2R isoform 2. Subcellular Location: Cytoplasm. Nucleus. Similarity: Belongs to the peptidase蛋白酶体PSMα3抗体 T1A family. Gene ID: 5684 Database links: Entrez Gene: 5684 Human Entrez Gene: 19167 Mouse Entrez Gene: 29670 Rat Entrez Gene: 408248 Rat Omim: 176843 Human SwissProt: P25788 Human SwissProt: O70435 Mouse SwissProt: P18422 Rat Unigene: 558799 Human Unigene: 296338 Mouse Unigene: 3997 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
蛋白酶体PSMα3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 细胞周期蛋白 细胞分化
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid