磷酸化蛋白酶体PSMβ7抗体

磷酸化蛋白酶体PSMβ7抗体

规格：1mg/1ml

英文名： phospho-Proteasome 20S beta 7(Ser214)

别名： Proteasome 20S beta 7 (phospho S214); Proteasome 20S beta 7 (phospho Ser214); p-Proteasome 20S beta 7 (S214); p-Proteasome 20S beta 7 (Ser214); 20S Proteasome β7; Macropain chain Z; Multicatalytic end

分子量： 25kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated Synthesised phosphopeptide derived from human

交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,

细胞定位：细胞核 细胞浆

磷酸化蛋白酶体PSMβ7抗体产品介绍：background: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of the trypsin-like activity.The proteasome represents a large protein complex that exists inside all eukaryotes and archaea, and in some bacteria. The main function of proteasomes is to degrade unnecessary or damaged proteins by proteolysis. The most common form of the proteasome, known as the 26S Proteasome, contains one 20S Proteasome core particle structure and two 19S regulatory caps. The 20S Proteasome core is hollow and forms an enclosed cavity, where proteins are degraded, as well as openings at the two ends to allow the target protein to enter. The 20S Proteasome core particle contains many subunits, depending on the organism. Function: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This unit is responsible of 磷酸化蛋白酶体PSMβ7抗体the trypsin-like activity. Subunit: The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic equivalent immune-specific subunit PSMB10. Interacts with HIV-1 TAT protein. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Expressed at a low level in colonic mucosa. Up-regulated in colorectal cancer tissues. Similarity: Belongs to the peptidase T1B family. Gene ID: 5695 Database links: Entrez Gene: 5695 Human 磷酸化蛋白酶体PSMβ7抗体Entrez Gene: 19177 Mouse Entrez Gene: 100037992 Pig Entrez Gene: 85492 Rat Omim: 604030 Human SwissProt: Q2TBP0 Cow SwissProt: Q99436 Human SwissProt: P70195 Mouse SwissProt: A1XQU1 Pig SwissProt: Q9JHW0 Rat Unigene: 213470 Human Unigene: 389251 Mouse Unigene: 3846 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

磷酸化蛋白酶体PSMβ7抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  细胞生物  细胞周期蛋白  细胞分化  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid

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