膜相关环指蛋白2抗体
规格：1mg/1ml
英文名： 42431
别名： E3 ubiquitin protein ligase MARCH2; E3 ubiquitin-protein ligase MARCH2; EC 6.3.2.- antibody HSPC240; MARCH II; MARCH-II; march2; MARH2_HUMAN antibody Membrane associated RING CH protein II; Membrane a
分子量： 27kDa品
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MARCH2
交叉反应：Human, Mouse, Rat,
膜相关环指蛋白2抗体细胞定位：细胞浆 细胞膜
产品介绍：background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH2 (membrane-associated ring finger (C3HC4) 2), also known as RNF172 or HSPC240, is a 246 amino acid multi-pass membrane protein that localizes to the endoplasmic reticulum and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, MARCH2 functions as an E3 ubiquitin-protein ligase that is thought to mediate the ubiquitination and subsequent degradation of CD71 and B7-2 and may be involved in endosomal protein trafficking. Function: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies.膜相关环指蛋白2抗体E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6. Subunit: Interacts with STX6 (By similarity). Interacts with MARCH3. Subcellular Location: Endoplasmic reticulum membrane. Lysosome membrane. Endosome membrane. Tissue Specificity: Broadly expressed. Similarity: Contains 1 RING-CH-type zinc finger. Gene ID: 51257 Database links: Entrez Gene: 51257 Human Entrez Gene: 膜相关环指蛋白2抗体224703 Mouse Entrez Gene: 362849 Rat Omim: 613332 Human SwissProt: Q9P0N8 Human SwissProt: Q99M02 Mouse SwissProt: Q5I0I2 Rat Unigene: 631861 Human Unigene: 374865 Mouse Unigene: 145219 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
膜相关环指蛋白2抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 通道蛋白 锌指蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid