膜相关环指蛋白3抗体
规格：1mg/1ml
英文名： 42432
别名： E3 ubiquitin-protein ligase MARCH3; FLJ20096; MARCH-III; March3; MARH3_HUMAN; Membrane associated ring finger (C3HC4) 3; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MARCH3
交叉反应：Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
膜相关环指蛋白3抗体产品介绍：background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH3 (membrane-associated ring finger (C3HC4) 3), also known as RNF173, is a 253 amino acid multi-pass membrane protein that localizes to cytoplasmic vesicles and early endosomes and contains one RING-CH-type zinc finger. Involved in the pathway of protein modification, MARCH3 functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to be involved in endosomal trafficking events.膜相关环指蛋白3抗体 Function: E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). Subunit: Interacts with MARCH2 and STX6 (By similarity). Subcellular Location: Cytoplasmic vesicle membrane. Early endosome membrane. Similarity: Contains 1 RING-CH-type zinc finger. Gene ID: 115123 Database links: Entrez Gene: 115123 Human Entrez Gene: 320253 Mouse Entrez Gene: 364878 Rat 膜相关环指蛋白3抗体Omim: 613333 Human SwissProt: Q86UD3 Human SwissProt: Q8BRX9 Mouse SwissProt: Q5XIE5 Rat Unigene: 132441 Human Unigene: 312623 Mouse Unigene: 203312 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
膜相关环指蛋白3抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 通道蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid