膜相关环指蛋白5抗体
规格：1mg/1ml
英文名： 42434
别名： E3 ubiquitin-protein ligase MARCH5; MARCH-V; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; RING finger protein 153.
分子量： 31kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MARCH5
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow,
细胞定位：细胞浆 细胞膜
膜相关环指蛋白5抗体产品介绍：background: MARCH5 is a member of the E3 ubiquitin-protein ligase family. This mitochonrial E3 ubiquitin-protein ligase plays an importnat role in controlling the morphology of the mitochondria. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH5 has been shown to interact with MTFN2 and ubiquitinated forms of DRP1. Function: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. Subunit: Monomer and homodimer. Interacts with膜相关环指蛋白5抗体 MFN1, MFN2, DNM1L and FIS1. Subcellular Location: Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301). Tissue Specificity: Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle. Post-translational modifications: Autoubiquitinated leading to degradation (short half-life). Similarity: Contains 1膜相关环指蛋白5抗体 RING-CH-type zinc finger. Gene ID: 54708 Database links: Entrez Gene: 54708 Human Entrez Gene: 69104 Mouse Entrez Gene: 294079 Rat Omim: 610637 Human SwissProt: Q9NX47 Human Unigene: 573490 Human Unigene: 175989 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
膜相关环指蛋白5抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 信号转导 细胞周期蛋白 通道蛋白 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid