ASTE1蛋白抗体
规格：1mg/1ml
英文名： ASTE1
别名： ASTE1; ASTE1_HUMAN; Asteroid homolog 1 (Drosophila); HT001; MGC129980; OTTHUMP; Protein asteroid homolog 1.
分子量： 77kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human ASTE1
交叉反应：Human, Mouse, Rat, Rabbit,
细胞定位：
ASTE1蛋白抗体品介绍：background: ASTE1 is a 679 amino acid protein that belongs to the asteroid family. Encoded by a gene that maps to human chromosome 3q22.1, ASTE1 is conserved in chimpanzee, cow, mouse, rat and zebrafish. ASTE1 is strongly linked to tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability, with lymphocyte density correlating to frameshift mutation presence and frequency within ASTE1. Severe colorectal dysplasia with microsatellite instability also exhibits frameshift mutations within ASTE1蛋白抗体ASTE1, suggesting that ASTE1 mutations occur early during microsatellite instability-induced colorectal carcinogenesis. ASTE1 frameshift mutations may generate a premature stop codon in the last exon that does not result in nonsense-mediated mRNA decay, thereby allowing mutated ASTE1 proteins to be highly expressed and exceptionally immunogenic. Frameshift mutations in ASTE1 are also linked to the manifestation of neoantigens, potentially recognized by T cells, possibly resulting in specific immune responses against specific neoantigens. Function: Possible role in EGF receptorASTE1蛋白抗体 signaling (By similarity). Similarity: Belongs to the asteroid family. Database links: Entrez Gene: 28990 Human SwissProt: Q2TB18 Human Unigene: 100878 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ASTE1蛋白抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid