跨膜蛋白165抗体
规格：1mg/1ml
英文名： TMEM165
别名： TM165_HUMAN; TMEM165; TMPT27; TPARL; Transmembrane protein 165; Transmembrane protein PT27; Transmembrane protein TPARL.
分子量： 35kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human TMEM165
交叉反应：Human, Mouse, Rat,
细胞定位：细胞膜
跨膜蛋白165抗体产品介绍：background: This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] Function: May function as a calcium/proton transporter involved in calcium and in lysosomal pH homeostasis. Therefore, it may play an indirect role in protein glycosylation. Subcellular Location: Membrane. Tissue Specificity: Ubiquitously expressed. Similarity: Belongs to the GDT1 family. Database links: Entrez Gene: 55858 Human Entrez Gene:跨膜蛋白165抗体 21982 Mouse Entrez Gene: 364137 Rat SwissProt: Q9HC07 Human SwissProt: P52875 Mouse SwissProt: Q4V899 Rat Unigene: 479766 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. The disease is caused by mutations affecting the gene represented in this entry. Disease description:An autosomal recessive disorder with a variable phenotype. Affected individuals show psychomotor retardation and growth retardation, and most have short stature. Other features跨膜蛋白165抗体 include dysmorphism, hypotonia, eye abnormalities, acquired microcephaly, hepatomegaly, and skeletal dysplasia. Congenital disorders of glycosylation are caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins and a wide variety of clinical features. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
跨膜蛋白165抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 信号转导 跨膜蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid