碱性核蛋白1/锌指蛋白basonuclin抗体
规格：1mg/1ml
英文名： BNC1
别名： basonuclin; basonuclin 1; basonuclin1; basonuclin-1; BNC; Bnc1; BNC1_HUMAN; BSN1; HsT19447; zinc finger protein basonuclin; Zinc finger protein basonuclin-1.
分子量： 111kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Basonucl
交叉反应：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
细胞定位：细胞核 细胞浆
碱性核蛋白1/锌指蛋白basonuclin抗体产品介绍：background: The zinc finger protein, basonuclin, is a putative rDNA transcription factor with highly restricted tissue distribution. Basonuclin is abundantly expressed in keratinocytes of the basal layer of the epidermis, the outer sheath of hair follicles and in the germ cells of the testis and ovary. Although basonuclin is associated with chromatin throughout the cell cycle, including mitosis, it disappears when cells become post-mitotic. In the epidermis, basonuclin, which is mainly localized to the cytoplasm, translocates to basal cell nuclei during different stages of keratinocyte growth. Basonuclin may enhance rRNA synthesis by elevating transcription from an rDNA promoter and inhibiting RNA polymerase I transcription through its zinc finger domain. Therefore, basonuclin may be a cell-type-specific 碱性核蛋白1/锌指蛋白basonuclin抗体transcription factor for rDNA transcription. Function: Likely to be a transcription factor specific for squamous epithelium and for the constituent keratinocytes at a stage either prior to or at the very beginning of terminal differentiation. May play a role in the differentiation of spermatozoa and oocytes. Subcellular Location: Nucleus. Cytoplasm. Relocates to the midpiece of the flagellum during late spermiogenesis in spermatids. Tissue Specificity: Expressed in epidermis, testis and foreskin, and to a lower extent in thymus, spleen, mammary glands碱性核蛋白1/锌指蛋白basonuclin抗体, placenta, brain and heart. Post-translational modifications: Phosphorylation on Ser-537 and Ser-541 leads to cytoplasmic localization. Similarity: Contains 6 C2H2-type zinc fingers. Gene ID: 646 Database links: Entrez Gene: 646 Human Omim: 601930 Human SwissProt: Q01954 Human Unigene: 459153 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
碱性核蛋白1/锌指蛋白basonuclin抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 细胞周期蛋白 转录调节因子 细胞分化 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid