环指蛋白170抗体
规格：1mg/1ml
英文名： RNF170
别名： Putative LAG1 interacting protein; Ring finger protein 170; RN170_HUMAN.
分子量： 30kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RNF170
交叉反应：Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
环指蛋白170抗体产品介绍：background: The ring finger is a specialized type of zinc finger of 40 to 60 residues that binds two atoms of zinc and mediates protein-protein interactions. There are five known isoforms of RNF170. Function: E3 ubiquitin-protein ligase that plays an essential role in stimulus-induced inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) ubiquitination and degradation via the endoplasmic reticulum-associated degradation (ERAD) pathway. Also involved in ITPR1 turnover in resting cells. Subunit: Constitutively associated with the ERLIN1/ERLIN 2 complex. Interacts with activated ITPR1. Subcellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Tissue Specificity: Expressed in the spinal chord. DISEASE: Defects in RNF170 are the cause of ataxia, sensory, type 1, 环指蛋白170抗体autosomal dominant (SNAX1) [MIM:608984]. A rare disease characterized by progressive ataxia caused by degeneration of the posterior columns of the spinal cord. Affected individuals have a reduced ability to feel pain, temperature and vibration, particularly in the hands and feet. Their most prominent feature is an ataxic gait resulting from a severe loss of proprioception. Thus, patients rely on visual cues for maintaining proper body posture, such that they are unable to remain upright if their eyes are closed (Romberg sign). Similarity: Contains 1 RING-type zinc finger. Gene ID:环指蛋白170抗体 81790 Database links: Entrez Gene: 81790 Human Entrez Gene: 77733 Mouse SwissProt: Q96K19 Human SwissProt: Q8CBG9 Mouse Unigene: 696153 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白170抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit