环指蛋白185抗体
规格：1mg/1ml
英文名： RNF185
别名： FLJ38628; Ring finger protein 185; RN185_HUMAN.
分子量： 20kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RNF185
交叉反应：Human, Mouse, Rat, Chicken, Horse, Sheep,
细胞定位：细胞浆 细胞膜
环指蛋白185抗体产品介绍：background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF185 (ring finger protein 185), also known as FLJ38628, is a 192 amino acid multi-pass membrane protein containing one RING-type zinc finger. Two RNF185 isoforms exist as a result of alternative splicing, and the gene encoding RNF185 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. 环指蛋白185抗体Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Function: Mitochondrial E3 ubiquitin-protein ligase that regulatesselective mitochondrial autophagy by mediating 'Lys-63'-linkedpolyubiquitination of BNIP1. Subunit: Interacts with ATG5 and BNIP1. Subcellular Location: Mitochondrion outer membrane; Multi pass membrane protein Similarity: Contains 1 RING-type zinc finger. Gene ID: 91445 Database links: Entrez Gene: 91445 Human环指蛋白185抗体 Entrez Gene: 193670 Mouse SwissProt: Q96GF1 Human SwissProt: Q91YT2 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白185抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid