去泛素酶10抗体
规格：1mg/1ml
英文名： USP10
别名： Deubiquitinating enzyme 10; Ubiquitin carboxyl terminal hydrolase 10; Ubiquitin carboxyl-terminal hydrolase 10; Ubiquitin specific peptidase 10; Ubiquitin specific processing protease 10; Ubiquitin sp
分子量： 87kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human USP10
交叉反应：Human, Mouse, Rat, Chicken, Dog, Pig, Horse, Rabbit,
细胞定位：细胞核 细胞浆
去泛素酶10抗体产品介绍：background: Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]. Function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to去泛素酶10抗体 regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Subunit: Interacts with G3BP, which may regulate its function. Interacts with p53/TP53, SNX3 and CFTR. Subcellular Location: Cytoplasm. Nucleus. Early endosome. Note=Cytoplasmic in normal conditions. After DNA damage, translocates to the nucleus following phosphorylation by ATM.去泛素酶10抗体 Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylated by ATM following DNA damage, leading to stablization and translocation it to the nucleus. Ubiquitinated. Deubiquitinated by USP13. Similarity: Belongs to the peptidase C19 family. USP10 subfamily. Gene ID: 9100 Database links: Entrez Gene: 9100 Human Entrez Gene: 479625 Dog Entrez Gene: 22224 Mouse Entrez Gene: 307905 Rat Omim: 609818 Human SwissProt: Q14694 Human SwissProt: P52479 Mouse SwissProt: Q3KR59 Rat Unigene: 19403 Dog Unigene: 136778 Human Unigene: 256910 Mouse Unigene: 421337 Mouse Unigene: 24862 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
去泛素酶10抗体applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 细胞生物 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid