尾侧型同源转录因子1抗体
规格：1mg/1ml
英文名： CDX1
别名： Caudal type homeo box transcription factor 1; Caudal type homeobox 1; Caudal type homeobox protein; Caudal type homeobox protein CDX1; Caudal type homeobox transcription factor 1; Caudal-type homeobox
分子量： 28kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human CDX1
交叉反应：Human, Mouse, Rat, Chicken, Horse, Sheep,
细胞定位：细胞核
尾侧型同源转录因子1抗体产品介绍：background: The members of the murine Cdx family (Cdx1, Cdx2, and Cdx4) are members of the caudal-type homeobox family of genes, which are homologues of the Drosophila ‘caudal’ gene required for anterior-posterior regional identity. The intestine-specific transcription factors Cdx1 and Cdx2 are candidate genes for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. The relative expression of Cdx1 to Cdx2 protein may be important in the anterior to posterior patterning of the intestinal epithelium and in defining patterns of proliferation and differentiation along the crypt-villus axis. Expression of the Cdx1 homeobox gene in epithelial intestinal cells promotes cellular growth and differentiation. Cdx1 positively regulates its own expression. Cdx1 and Cdx2尾侧型同源转录因子1抗体 are expressed in the small intestine and colon of fetus and *****. A decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis. Both Cdx1 and Cdx2 genes must be expressed to reduce tumorigenic potential, to increase sensitivity to apoptosis and to reduce cell migration, suggesting that the two genes control the normal phenotype by independent pathways. The human 尾侧型同源转录因子1抗体Cdx1 gene maps to chromosome 5q31-q33 and encodes a 265-amino acid protein. Function: Could play a role in the terminal differentiation of the intestine. Subcellular Location: Nucleus. Tissue Specificity: Intestinal epithelium. Similarity: Belongs to the Caudal homeobox family. Contains 1 homeobox DNA-binding domain. Gene ID: 1044 Database links: Entrez Gene: 1044 Human Omim: 600746 Human SwissProt: P47902 Human Unigene: 1545 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
尾侧型同源转录因子1抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学 表观遗传学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid