环指蛋白35抗体
规格：1mg/1ml
英文名： RNF35
别名： RING finger protein 35; Gm319; Gm35; Gm865; ring finger protein 40; Ring finger RNF35; TRIM40; Tripartite motif containing 40; Tripartite motif containing protein 40; Tripartite motif protein 40; TRI4
分子量： 29kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RNF35
交叉反应：Human, Mouse, Rat, Pig, Cow,
细胞定位：
环指蛋白35抗体产品介绍：background: The tripartite motif (TRIM) family of proteins are characterized by a conserved TRIM domain that includes a coiled-coil region, a B-box type zinc finger, one RING finger and three zinc-binding domains. TRIM61 (Tripartite motif-containing protein 61), also known as RNF35 (RING finger protein 35), is a 209 amino acid protein that contains a variety of domains that are characteristic to TRIM proteins, including a RING-type zinc finger and a B box-type zinc finger. In mice, TRIM61 is temporarily transcribed in the early embryo, but then is permanently silenced before the blastocyst stage of development. Transcription of TRIM61 is positively regulated by nuclear factor Y (NF-Y). The gene encoding TRIM61 maps to human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene 环指蛋白35抗体deserts (regions of the genome with no protein encoding genes) of all of the human chromosomes. Function: May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity. Subunit: Interacts with NEDD8. Tissue Specificity: Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract. Similarity: Belongs to the TRIM/RBCC family.环指蛋白35抗体 Contains 1 B box-type zinc finger. Contains 1 RING-type zinc finger. Gene ID: 135644 Database links: Entrez Gene: 135644 Human Entrez Gene: 195359 Mouse Entrez Gene: 365528 Rat SwissProt: Q6P9F5 Human SwissProt: Q3UWA4 Mouse SwissProt: Q6MFY8 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白35抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid