环指蛋白130抗体
规格：1mg/1ml
英文名： RNF130
别名： GOLIATH; 2510042A13Rik; G1 related zinc finger protein; G1rp; G1RZFP; GP antibody MGC117241; MGC138647; MGC99542; R goliath; RING finger protein 130; GOLI_HUMAN.
分子量： 44kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human RNF130
交叉反应：Human, Mouse, Rat, Cow, Rabbit, Sheep,
细胞定位：细胞浆 细胞膜
环指蛋白130抗体产品介绍：background: The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain this conserved domain are generally involved in the ubiquitination pathway of protein degradation. RNF130 (ring finger protein 130), also known as GP, G1RZFP (G1-related zinc finger protein) or GOLIATH, is a 419 amino acid single-pass type I membrane protein that shares similarity with a Drosophila zinc-finger protein found in mesoderm known as g1. RNF130 contains one PA (protease associated) domain and a single RING-type zinc finger. Implicated in the regulation of growth factor withdrawal-induced apoptosis of myeloid precursor cells, RNF130 is encoded by a gene located on human chromosome 5q35.3 and mouse chromosome 11 B1.3. Function: May have a role during the programmed cell death of hematopoietic cells. Acts as an E3 ubiquitin-protein ligase. 环指蛋白130抗体Subcellular Location: Membrane; Single-pass type I membrane protein (Potential). Cytoplasm. Tissue Specificity: Ubiquitously expressed. Highly expressed in leukocytes. Not expressed in erythroblasts. Post-translational modifications: In vivo measurements suggest this protein is glycosylated (PubMed:19159218). In contrast, in vitro experiments failed to detect glycosylation (PubMed:16549277). Similarity: Contains 环指蛋白130抗体1 PA (protease associated) domain. Contains 1 RING-type zinc finger. Gene ID: 55819 Database links: Entrez Gene: 55819 Human Entrez Gene: 59044 Mouse SwissProt: Q86XS8 Human SwissProt: Q8VEM1 Mouse SwissProt: Q6Y290 Rat Unigene: 484363 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
环指蛋白130抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：细胞生物 **学
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid