抑制素结合蛋白抗体
规格：1mg/1ml
英文名： IGSF1
别名： PGSF2; IGCD1; IGDC1; Immunoglobulin like domain containing protein 1; Immunoglobulin superfamily member 1; InhBP; Inhibin binding protein; KIAA0364; p120; Pituitary gland specific factor 2; IGSF1_HUMA
分子量： 80, 144kDa
储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆类型：Polyclonal
亚型：IgG
纯化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human IGSF1
交叉反应：Human, Mouse, Rat, Dog, Pig, Horse,
细胞定位：细胞膜 分泌型蛋白
抑制素结合蛋白抗体产品介绍：background: IGSF1 is a highly glycolylated immunoglobulin domain-containing protein. IGSF1 has been shown to act as a coreceptor in inhibin signaling, however, it does not appear to be a high-affinity inhibin receptor by itself. May reduce or inhibit activin A signaling and is believed to be necessary in the mediation of specific effects of inhibin B on activin-stimulated transcription. IGSF1 has been found to interact with several members of the ACVR family and possibly some members of the BMPR group. There are 3 known isoforms of IGSF1, with 1 and 2 likely being multi-pass membrane proteins. Isoform 3 is believed to be expressed as a secreted form. Expression is high in pancreas, testis and fetal liver, while heart, prostate and small intestine show only moderate expression. IGSF1 may be found at very low levels in brain, muscle, thymus, ovary, colon, fetal lung and fetal kidney. Isoform 3 has been detected in pituitary gland. Function: Seems to be a coreceptor in inhibin signaling, but seems not to be a high-affinity inhibin receptor. Antagonizes activin A signaling in the presence or absence of inhibin B (By similarity). Necessary to mediate a specific antagonistic effect of inhibin B on activin-stimulated transcription. Subunit: Interacts with INHA (By similarity).抑制素结合蛋白抗体 In PubMed:12385827 does not interact with INHA; standard receptor binding assay. Interacts with ACVR1B; the interaction appears to be ligand-dependent as it is diminished by inhibin B and activin A. Interacts with ACVR2A, ACVR2B, ACVRL1 and BMPR1B. Interacts with HECTD1. Subcellular Location: Isoforms 1 and 2: Membrane; Multipass membrane protein (Potential). Isoform 3: Secreted. Tissue Specificity: Highly expressed in pancreas, testis and fetal liver. Moderately expressed in heart, prostate and small intestine. Expressed at very low levels in brain, thymus,抑制素结合蛋白抗体 ovary, colon, fetal lung and fetal kidney. Expressed in muscle. Isoform 3 is expressed in pituitary gland. Similarity: Contains 12 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 3547 Database links: Entrez Gene: 3547 Human Omim: 300137 Human SwissProt: Q8N6C5 Human Unigene: 22111 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产抑制素结合蛋白抗体品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究领域：肿瘤 信号转导 生长因子和** 结合蛋白
储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
来源： Rabbit
外观： Lyophilized or Liquid
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