环指蛋白98抗体

环指蛋白98抗体

规格：1mg/1ml

英文名： RNF98

别名： Acrosome RBCC protein; E3 ubiquitin protein ligase TRIM36; E3 ubiquitin-protein ligase Trim36; Haprin; RBCC728; Ring finger protein 98; TRI36_HUMAN; TRIM 36; TRIM36; Tripartite motif containing 36; Tr

分子量： 83kDa

储存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce

克隆类型：Polyclonal

亚型：IgG

纯化方法：affinity purified by Protein A

**原：KLH conjugated synthetic peptide derived from human TRIM36/R

交叉反应：Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,

细胞定位：细胞浆

环指蛋白98抗体产品介绍：background: TRIM36 (tripartite motif-containing 36), also known as RNF98 (RING finger protein 98), HAPRIN (haploid germ cell-specific RBCC protein) or RBCC728, is a 728 amino acid protein that belongs to the TRIM/RBCC (Ring finger, B box, coiled-coil) family. Predominantly expressed in prostate, testis and brain with weak expression in heart, kidney and lung, TRIM36 contains two B box-type zinc fingers, a SPRY domain, a coiled-coil domain, a fibronectin type-III domain and a RING-type zinc finger; a motif that has zinc-chelating activity and is involved in mediating protein-protein and protein-DNA interactions. Localizing to the cytoplasm and the acrosomal region of germ cells and mature sperm, TRIM36 is believed to play a role in the acrosome reaction and fertilization. In addition, TRIM36 is overexpressed in prostate cancer, suggesting a possible role for TRIM36 in prostate tumorigenesis. Function: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Involved in chromosome segregation and cell cycle regulation. May play a role in the acrosome reaction 环指蛋白98抗体and fertilization (By similarity). Subunit: Interacts with CENPH (By similarity). Subcellular Location: Cytoplasm (By similarity). Cytoplasmic vesicle, secretory vesicle, acrosome (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Found in the acrosomal region of elongated spermatids and mature sperm (By similarity). Tissue Specificity: Highly expressed in testis, prostate and brain. Weakly expressed in kidney, lung and heart. Similarity: Belongs to the TRIM/RBCC family. Contains 2 B box-type zinc fingers. Contains 1 B30.2/SPRY domain. Contains 1 COS domain.环指蛋白98抗体 Contains 1 fibronectin type-III domain. Contains 1 RING-type zinc finger. Gene ID: 55521 Database links: Entrez Gene: 55521 Human Entrez Gene: 28105 Mouse GenBank: NM_018700 Human GenBank: NM_178872 Mouse Omim: 609317 Human SwissProt: Q9NQ86 Human SwissProt: Q80WG7 Mouse Unigene: 519514 Human Unigene: 638953 Human Unigene: 277382 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

环指蛋白98抗体产品应用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.

研究领域：肿瘤  细胞生物  **学  

储存条件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

来源： Rabbit

外观： Lyophilized or Liquid

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